John Castle PhD

John is Chief Data Scientist at Monte Rosa Therapeutics. John has deep expertise in biomarkers and therapy development using computational biology, AI, biotechnology and genomics. John pioneered bioinformatics and ‘omics approaches to neoantigen identification for anti-tumor immunity, revolutionizing neoantigen vaccine and TCR platforms.

Prior to joining Monte Rosa Therapeutics, he was Associate Vice President for Translational Sciences at Agenus, served as associate director at Rosetta Inpharmatics/Merck & Co. and subsequently co-directed the Biomarker Development Center of Translational Oncology at the University of Mainz, Germany. John built the bioinformatics and genomics department at BioNTech AG. John studied physics at Rice University in Houston and at the University of Göttingen in Germany, was a Fulbright Scholar at the Australian National University in Canberra and received his Ph.D. in geophysics from the University of Washington in Seattle.