by myNEO Tx Admin | May 30, 2024 | Article, News
Following neoantigen discovery and validation, mRNA construct design can be challenging. Read this case study to learn more about how to design multi-epitope mRNA constructs to optimize translation efficiency and target-specific immunogenicity while avoiding...by myNEO Tx Admin | Nov 16, 2023 | Article, News
myNEO Therapeutics has been quite active in recent months, taking part in various conference presentations and participating in panel discussions about neoantigen discovery. Additionally, we’re pleased to announce that our CEO, Cedric, received the Medical...The process starts with the collection of both patient blood and a tumor biopsy.
Whole-Genome Sequencing data from matched tumor and normal DNA is required for each patient.
Following alignment of these reads to the genome, somatic gene alterations in the tumor genome are detected using a collection of algorithms called 'neoX'.
Next, these somatic gene alterations are translated in-silico to obtain the tumor-specific peptides
In a last step, the peptides are prioritized using an immunogenicity predictor (neoIM) and two presentation predictors (neoMS and MHCrank).