by Wim Mees | Aug 11, 2021 | Team events
This week we had a teambuilding activity with the myNEO team! We started the night with some serious action and jumped our way through the inflatable park of Jumpsky in Ghent. After that, we enjoyed a super tasty meal in the city centre of Ghent and we finished...by Wim Mees | Jun 10, 2021 | Team events
Due to corona, the myNEO team had to work fully remotely in the last months. As the regulations are finally becoming less strict, we decided to organize a small team event outside. We had some drinks accompanied with appetizers in the afternoon, followed by some...The process starts with the collection of both patient blood and a tumor biopsy.
Whole-Genome Sequencing data from matched tumor and normal DNA is required for each patient.
Following alignment of these reads to the genome, somatic gene alterations in the tumor genome are detected using a collection of algorithms called 'neoX'.
Next, these somatic gene alterations are translated in-silico to obtain the tumor-specific peptides
In a last step, the peptides are prioritized using an immunogenicity predictor (neoIM) and two presentation predictors (neoMS and MHCrank).