by Wim Mees | May 25, 2022 | Article, News, Press release
CureVac (Nasdaq: CVAC) and myNEO Therapeutics will partner to identify novel targets for mRNA-based cancer vaccine development. We’re convinced that combining our tumor characterization and neoantigen discovery methods with an mRNA vaccination technology holds great...by Wim Mees | Mar 1, 2022 | Team events
myNEO fully endorses a work hard/play hard balance and so we have at least once a month an afterwork drink or dinner. We think it is important to keep the team spirit alive to enable better interpersonal communication leading to more efficient team working...The process starts with the collection of both patient blood and a tumor biopsy.
Whole-Genome Sequencing data from matched tumor and normal DNA is required for each patient.
Following alignment of these reads to the genome, somatic gene alterations in the tumor genome are detected using a collection of algorithms called 'neoX'.
Next, these somatic gene alterations are translated in-silico to obtain the tumor-specific peptides
In a last step, the peptides are prioritized using an immunogenicity predictor (neoIM) and two presentation predictors (neoMS and MHCrank).